PUBLICATIONS

  1. Ameen SS, Griem-Krey N, Dufour A, Hossain MI, Hoque A, Sturgeon S, Nandurkar H, Draxler DF, Medcalf RL, Kamaruddin MA, Lucet IS, Leeming MG, Liu D, Dhillon A, Lim JP, Basheer F, Zhu HJ, Bokhari L, Roulston CL, Paradkar PN, Kleifeld O, Clarkson AN, Wellendorph P, Ciccotosto GD, Williamson NA, Ang CS, Cheng H C. N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection. Mol Cell Proteomics 2023, 22: 100543.
  2. Lui A, Vanleuven J, Perekopskiy D, Liu D, Xu D, Alzayat O, Elgokhy T, Do T, Gann M, Martin R, Liu DZ. FDA-Approved Kinase Inhibitors in Preclinical and Clinical Trials for Neurological Disorders. Pharmaceuticals, 2022; 15: 1546 (review)
  3. Lui A, Alzayat O, Do T, Perekopskiy D, Gann M, Elgokhy TS, Gao J, Liu DZ. Multi-targeted anti-inflammatory drugs for the treatment of neurological disorders. Neural Regen Res. 2023 Apr;18(4):805-806. PMID: 36204844 (Perspective)
  4. Ye Z, Izadi A, Gurkoff GG, Rickerl K, Sharp FR, Ander BP, Bauer AZ, Lui A, Lyeth BG, Liu DZ. Combined Inhibition of Fyn and c-Src Protects Hippocampal Neurons and Improves Spatial Memory via ROCK after Traumatic Brain Injury. J Neurotrauma. 2022 Apr;39(7-8):520-529. PMID: 35109711
  5. Durocher M, Ander BP, Jickling G, Hamade F, Hull H, Knepp B, Liu DZ, Zhan X, Tran A, Cheng X, Ng K, Yee A, Sharp FR, Stamova B. Inflammatory, regulatory, and autophagy co-expression modules and hub genes underlie the peripheral immune response to human intracerebral hemorrhage. J Neuroinflammation. 2019 Mar 5;16(1):56. PMID: 30836997
  6. Shroff N, Ander BP, Zhan X, Stamova B, Liu D, Hull H, Hamade FR, Dykstra-Aiello C, Ng K, Sharp FR, Jickling GC. HDAC9 Polymorphism Alters Blood Gene Expression in Patients with Large Vessel Atherosclerotic Stroke. Transl Stroke Res. 2019 Feb;10(1):19-25. PMID: 29651704
  7. Lv B, Cheng XY, Sharp FR, Ander BP, Liu DZ. Broad therapeutic window of miR-122 mimic to improve stroke outcome through indirect inhibition of NOS2. Front. Neurosci. 2018;12:767. PMID: 30405345
  8. Sun P, Liu DZ, Jickling GC, Sharp FR, Yin KJ. MicroRNA-based therapeutics in central nervous system injuries. J Cereb Blood Flow Metab. 2018 Jul;38(7):1125-1148. PMID: 29708005.
  9. Stamova B, Ander BP, Jickling G, Hamade F, Durocher M, Zhan X, Liu DZ, Cheng X, Hull H, Yee A, Ng K, Shroff N, Sharp FR. The intracerebral hemorrhage blood transcriptome in humans differs from the ischemic stroke and vascular risk factor control blood transcriptomes. J Cereb Blood Flow Metab. 2019 Sep;39(9):1818-1835. PMID: 29651892
  10. Liu DZ, Waldau B, Ander BP, Zhan X, Stamova B, Jickling GC, Lyeth BG, Sharp FR. Inhibition of Src Family Kinases Improves Cognitive Function after Intraventricular Hemorrhage or Intraventricular Thrombin. J Cereb Blood Flow Metab. 2017 Jul;37(7):2359-2367. PMID: 26661204
  11. Liu DZ. Repurposing cancer drugs to treat neurological diseases – Src inhibitors as examples. Neural Regen Res. 2017 Jun;12(6):910-911. PMID: 28761420
  12. Dykstra-Aiello C, Jickling GC, Ander BP, Shroff N, Zhan X, Liu D, Hull H, Orantia M, Stamova BS, Sharp FR. Altered Expression of Long Noncoding RNAs in Blood After Ischemic Stroke and Proximity to Putative Stroke Risk Loci. Stroke. 2016; 47(12):2896-2903. PMID: 27834745
  13. Jickling GC, Ander BP, Shroff N, Miles O, Stamova B, Dykstra-Aiello C, Hull H, Zhan X, Liu DZ, Sharp FR. Leukocyte response is regulated by microRNA let7i in patients with acute ischemic stroke. Neurology. 2016; 87(21):2198-2205. PMID: 27784773
  14. Liu DZ, Jickling GC, Ander BP, Hull H, Zhan X, Cox C, Shroff N, Dykstra-Aiello C, Stamova B, Sharp FR. Elevating microRNA-122 in blood improves outcomes after temporary middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2016;36(8):1374-83. PMID:26661204
  15. Liu DZ, Stamova B, Hu S, Ander BP, Jickling GC, Zhan X, Sharp FR, Wong B. MicroRNA and mRNA expression changes in steroid naïve and steroid treated DMD patients. J Neuromuscul Dis. 2015;2(4):387-96
  16. Liu D, Zhang X, Hu BL, Ander BP. Src Family Kinases in Brain Edema after Acute Brain Injury. Acta Neurochir Suppl. 2016;121:185-90. PMID: 26463946.
  17. Dykstra-Aiello C, Jickling GC, Ander BP, Zhan X, Liu D, Hull H, Orantia M, Ho C, Stamova B. Intracerebral Hemorrhage and Ischemic Stroke of Different Etiologies Have Distinct Alternatively Spliced mRNA Profiles in the Blood: a Pilot RNA-seq Study. Transl Stroke Res. 2015 Aug;6(4):284-9. PMID: 25994285
  18. Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR. Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab. 2015 Jun;35(6):888-901. PMID: 25806703.
  19. Zhan X, Jickling GC, Ander BP, Stamova B, Liu D, Kao PF, Zelin MA, Jin LW, DeCarli C, Sharp FR. Myelin basic protein associates with AβPP, Aβ1-42, and amyloid plaques in cortex of Alzheimer’s disease brain. J Alzheimers Dis. 2015;44(4):1213-29. PMID: 25697841
  20. Zhan X, Cox C, Ander BP, Liu D, Stamova B, Jin LW, Jickling GC, Sharp FR. Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain.J Alzheimers Dis. 2015;46(2):507-23. PMID: 25790832
  21. Liu DZ, Sharp FR, Van KC, Ander BP, Ghiasvand R, Stamova B, Zhan X, Jickling GC, Lyeth BG. Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury. J Neurotrauma. 2014 Jul 15;31(14):1268-76. PMID: 24428562
  22. Bai Z, Stamova B, Xu H, Ander BP, Wang J, Jickling GC, Zhan X, Liu D, Han G, Jin LW, Decarli C, Lei H, Sharp FR. Distinctive RNA Expression Profiles in Blood Associated With Alzheimer Disease After Accounting for White Matter Hyperintensities. Alzheimer Dis Assoc Disord. 2014 Jul-Sep;28(3):226-33. PMID: 24731980
  23. Zhan X, Jickling GC, Ander BP, Liu D, Stamova B, Cox C, Jin LW, DeCarli C, Sharp FR. Myelin injury and degraded myelin vesicles in Alzheimer’s disease. Curr Alzheimer Res. 2014 Mar;11(3):232-8. PMID: 24484278
  24. Jickling GC, Ander BP, Zhan X, Noblett D, Stamova B, Liu D. microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted GeneTargets. PLos One. 2014 Jun 9;9(6):e99283. PMID: 24911610
  25. Jickling GC, Ander BP, Zhan X, Noblett D, Stamova B, Liu D. microRNA Expression in Peripheral Blood Cells following Acute Ischemic Stroke and Their Predicted GeneTargets. PLos One. 2014 Jun 9;9(6):e99283. PMID: 24911610
  26. Stamova B, Jickling GC, Ander BP, Zhan X, Liu D, Turner R, Ho C, Khoury JC, Bushnell C, Pancioli A, Jauch EC, Broderick JP, Sharp FR. Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One. 2014 Jul 18;9(7):e102550. PMID: 25036109
  27. Sharp FR, Zhan X and Liu DZ. Heat Shock Proteins in Brain: Role of Hsp70, Hsp 27 and HO-1 (Hsp32) and Their Therapeutic Potential. Translational Stroke Research 2013 2013 Dec;4(6):685-92. PMID: 24323422.
  28. Jickling GC, Ander BP, Stamova B, Zhan X, Liu D, Bsc LR, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. RNA in blood is altered prior to hemorrhagic transformation in ischemic stroke. Ann Neurol. 2013 Aug;74(2):232-40. PMID: 23468366
  29. Gunther J, Tian Y, Stamova B, Lit L, Corbett B, Ander B, Zhan X, Jickling G, Bos-Veneman N, Liu D, Hoekstra P, Sharp F.  Catecholamine-related gene expression in blood correlates with tic severity in tourette syndrome.Psychiatry Res. 2012 Dec 30;200(2-3):593-601. PMID: 22648010
  30. Jickling GC, Stamova B, Ander BP, Zhan X, Liu D, Sison SM, Verro P, Sharp FR. Prediction of cardioembolic, arterial, and lacunar causes of cryptogenic stroke by gene expression and infarct location. Stroke. 2012 Aug;43(8):2036-41. PMID:22627989
  31. Liu DZ, Sharp FR. Excitatory and Mitogenic Signaling in Cell Death, Blood–brain Barrier Breakdown, and BBB Repair after Intracerebral Hemorrhage. Translational Stroke Research 2012 Jul;3(Suppl 1):62-9. Review.
  32. Tian Y, Stamova B, Jickling GC, Xu H, Liu D, Ander BP, Bushnell C, Zhan X, Turner RJ, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Y Chromosome Gene Expression in the Blood of Male Patients With Ischemic Stroke Compared With Male Controls. Gend Med. 2012 Apr;9(2):68-75. PMID: 22365286
  33. Tian Y, Stamova B, Jickling GC, Liu D, Ander BP, Bushnell C, Zhan X, Davis RR, Verro P, Pevec WC, Hedayati N, Dawson DL, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Effects of gender on gene expression in the blood of ischemic stroke patients. J Cereb Blood Flow Metab. 2012 May;32(5):780-91. PMID: 22167233
  34. Jickling GC, Zhan X, Stamova B, Ander BP, Tian Y, Liu D, Sison SM, Verro P, Johnston SC, Sharp FR. Ischemic Transient Neurological Events Identified by Immune Response to Cerebral Ischemia. Stroke. 2012;43(4):1006-12. PMID: 22308247
  35. Liu DZ, Ander BP, Tian Y, Stamova B, Jickling G, Davis RR, Sharp FR. Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells. Gene 2012; 495:120-127. PMID: 22244746
  36. Stamova B, Tian Y, Jickling G, Bushnell C, Zhan X, Liu D, Ander BP, Verro P, Vihar P, Pevec WC, Hedayati N, Dawson DL, Jauch EC, Pancioli A, Broderick JP, Sharp FR. The X-chromosome has a different pattern of gene expression in women compared to men with ischemic stroke. Stroke 2012 Feb;43(2):326-34 PMID: 22052522
  37. Liu DZ, Ander BP, Cell Cycle Inhibition without Disruption of Neurogenesis is a Strategy for Treatment of Aberrant Cell Cycle Diseases: an Update. ScientificWorldJournal. 2012; 2012:491737. PMID: 22547985
  38. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Ander BP, Cox C, Kuczynski B, Liu D. RNA Expression Profiles From Blood for the Diagnosis of Stroke and Its Causes. J Child Neurol. 2011 Jun; 26(9):1131-6. PMID: 21636778.
  39. Jickling GC, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Xu H, Johnston SC, Verro P, Sharp FR. Profiles of lacunar and nonlacunar stroke. Ann Neurol. 2011 Sep;70(3):477-85. PMID: 21796664
  40. Sharp FR, Jickling GC, Stamova B, Tian Y, Zhan X, Liu D, Kuczynski B, Cox CD, Ander BP. Molecular markers and mechanisms of stroke: RNA studies of blood in animals and humans. J Cereb Blood Flow Metab. 2011 Jul;31(7):1513-31. . PMID: 21505474.
  41. Tian Y, Gunther JR, Liao IH, Liu D, Ander BP, Stamova BS, Lit L, Jickling GC, Xu H, Zhan X, Sharp FR. GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: A pilot study. Brain ResMar 24;1381:228-36. PMID: 21241679
  42. Liu DZ, Sharp FR. The Dual Role of Src Kinases in Intracerebral Hemorrhage. Acta Neurochir Suppl. 111:77-81.PMID: 21725735.
  43. Tian Y, Liao IH, Zhan X, Gunther JR, Ander BP, Liu D, Lit L, Jickling GC, Corbett BA, Bos-Veneman NG, Hoekstra PJ, Sharp FR. Exon expression and alternatively spliced genes in Tourette Syndrome. Am J Med Genet B Neuropsychiatr GenetJan;156B(1):72-8. PMID: 21184586
  44.  Tian Y, Apperson ML, Ander BP, Liu D, Stomova BS, Jickling GC, Enriquez R, Agius MA, Sharp FR. Differences in exon expression and alternatively spliced genes in blood of multiple sclerosis compared to healthy control subjects. J NeuroimmunolJan;230(1-2):124-9.PMID: 20920832
  45. Xu H, Stamova B, Jickling G, Tian Y, Zhan X, Ander BP, Liu D, Turner R, Rosand J, Goldstein LB, Furie KL, Verro P, Johnston SC, Sharp FR, Decarli CS. Distinctive RNA Expression Profiles in Blood Associated with White Matter Hyperintensities in Brain. Stroke 2010 Dec;41(12):2744-9. PMID: 20966416
  46. Jickling GC, Xu H, Stamova B, Ander BP, Zhan X, Tian Y, Liu D, Turner RJ, Mesias M, Verro P, Khoury J, Jauch EC, Pancioli A, Broderick JP, Sharp FR. Signatures of cardioembolic and large vessel ischemic stroke. Ann Neurol. 2010 Nov;68(5):681-92. PMID: 21031583
  47.  Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczyk P, Zhan X, Liu D, Ander BP, Liao IH, Gregg JP, Turner RJ, Jickling G, Lit L, Sharp FR., Gene Expression Profiling of Blood for the Prediction of Ischemic Stroke. Stroke 2010 Oct; 41(10):2171-7. PMID: 20798371
  48. Jickling GC, Zhan X, Ander BP, Turner RJ, Stamova B, Xu H, Tian Y, Liu D, Davis RR, Lapchak PA, Sharp FR. Genome response to tissue plasminogen activator in experimental ischemic stroke. BMC Genomics PMID: 20406488
  49. Liu DZ, Ander BP, Xu H, Shen Y, Kaur P, Deng W, Sharp FR. Blood brain barrier breakdown and repair after thrombin-induced brain injury. Ann Neurol PMID: 20437588
  50.   Liu DZ, Ander BP, Sharp FR. Cell cycle inhibition without disruption of neurogenesis is a strategy in treatment of central nervous system diseases. Neurobiol Dis. PMID: 19944161
  51. Zhan X, Ander BP, Jickling G, Turner R, Stamova B, Xu H, Liu D, Davis RR, Sharp FR. Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood. J Cereb Blood Flow Metab. PMID: 19738631
  52. Liu DZ, Tian Y, Ander BP, Xu H, Stamova B, Zhan X, Turner RJ, Jickling G, Sharp FR. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage and kainate seizures. J Cereb Blood Flow Metab. PMID: 19724284
  53. Lit L, Sharp FR, Apperson M, Liu DZ, Walker WL, Liao I, Xu H, Ander BP, Wong B. Corticosteroid effects on blood gene expression in Duchenne muscular dystrophy. Pharmacogenomics J. 2009 Dec;9(6):411-8. PMID: 19488064
  54. Stamova BS, Apperson M, Walker WL, Tian Y, Xu H, Adamczyk P, Zhan X, Liu DZ, Ander BP, Liao IH, Gregg JP, Turner RJ, Jickling G, Lit L, Sharp FR. Identification and Validation of Suitable Endogenous Reference Genes for Gene Expression Studies in Human Peripheral Blood. BMC Med Genomics. 2009 Aug 5;2(1):49. PMID: 19656400
  55. Xu H, Tang Y, Liu DZ, Ran R, Ander BP, Apperson M, Liu XS, Khoury JC, Gregg JP, Pancioli A, Jauch EC, Wagner KR, Verro P, Broderick JP, Sharp FR. Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic stroke. J Cereb Blood Flow Metab. 2008 Jul;28(7):1320-8. PMID: 18382470
  56. Liu DZ, Cheng XY, Ander BP, Xu H, Davis RR, Gregg JP, Sharp FR. Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons. Neurobiol Dis. 2008 May;30(2):201-11. PMID: 18343677
  57. Sharp F, Liu DZ, Zhan X, Ander BP. Intracerebral hemorrhage injury mechanisms: glutmate neurotoxicity, thrombin, and Src. Acta Neurochir Suppl. 105: 43-46. PMID: 19066080. Review
  58. Liu DZ, Zhu J, Jin DZ, Zhang LM, Ji XQ, Ye Y, Tang CP, Zhu XZ. Behavioral recoveryfollowing sub-chronic paeoniflorin administration in the striatal 6-OHDA lesion rodent model of Parkinson’s disease. Journal of Ethnopharmacology. 2007 Jun 13;112(2):327-32. PMID: 17451897
  59. Sharp FR, Xu H, Lit L, Walker W, Apperson M, Gilbert DL, Glauser TA, Wong B, Hershey A, Liu DZ, Pinter J, Zhan X, Liu X, Ran R. The future of genomic profiling of neurological diseases using blood. Arch Neurol. 2006 Nov;63(11):1529-36. PMID: 17101821.
  60. Liu DZ, Zhao FL, Liu J, Ji XQ, Ye Y, Zhu XZ. Potentiation of adenosine A1 receptor agonist CPA-induced antinociception by paeoniflorin in mice. Biol Pharm Bull. 2006 Aug; 29(8):1630-3. PMID: 16880617
  61. Qiu WW, Xu J, Liu DZ, Li JY, Ye Y, Zhu XZ, Li J, Nan FJ. Design and synthesis of a biotin-tagged photoaffinity probe of paeoniflorin. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3306-9. PMID: 16621531
  62. Chen YH, Zhang YH, Zhang HJ, Liu DZ, Gu M, Li JY, Wu F, Zhu XZ, Li J, Nan FJ. Design, synthesis, and biological evaluation of isoquinoline-1,3,4-trione derivatives as potent caspase-3 inhibitors. Journal of Medical Chemistry. 2006 Mar 9;49(5):1613-23. PMID: 16509578
  63. Liu DZ, Xie KQ, Ji XQ, Ye Y, Jiang CL, Zhu XZ. Neuroprotective effect of paeoniflorin on cerebral ischemic rat by activating adenosine A1 receptor in a manner different from its classical agonists. British Journal of Pharmacology. 2005 Oct;146(4):604-11. PMID: 16086036

In transition from UC Davis to a new Institute